针对临床重大疾病治疗，基于生物学核心基本规律和全新理念，着重开展原创手性及特种药物的设计、合成及机制研究，利用新方法进行药物靶标确证等，此外亦进行多肽药物改造及工艺等工作。

主持项目：

1. 国家人社部留学人员科技活动择优资助优秀类项目：新型固相多肽合成，2016.05-，项目负责人;

2. 国家自然基金面上项目(21272107)：活性官能团导向的抗肿瘤全新化学实体的结构优化及作用机制研究，2013-2016，项目负责人;

3. 国家自然基金青年项目(21002043)：碱土金属催化的新型烯丙醇重排反应研究，2011-2013，项目负责人;

近年代表论文及专利：

[1] Lin, Li; Yang, Y. H.; Wang, M.; Lai, L. H.; Guo, Y. R.; Wang, R. Oxidative N-Heterocyclic Carbene Catalyzed Diastereoselective Annulation of Simple Aldehyde and 5-Alkenyl Thiazolone: Facile Asymmetric Synthesis of Chiral Thiazolo Pyrones, Chem. Commun. 2015, 51, 8134-8137.

[2] Chen, Q.; Zhou, J. W.; Wang, Y. N.; Wang, C.; Liu, X. H.; Xu, Z. Q.; Lin, Li; Wang, R. Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions, Org. Lett., 2015, 17, 4212–4215.

[3] Chen, Q.; Wang, G. Q.; Jiang, X. X.; Xu, Z. Q.; Lin, Li; Wang, R. Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters, Org. Lett., 2014, 16, 1394–1397.

[4] Zhu, L. P.; Yu, H. M.; Xu, Z. Q.; Jiang, X. X.; Lin, Li; Wang, R. Copper- Catalyzed Oxyazidation of Unactivated Alkenes: A Facile Synthesis of Isoxazolines Featuring an Azido Substituent, Org. Lett., 2014, 16, 1562–1565.

[5] Zhang, J. L.; Yang, Y. H.; Wang, M.; Lin, Li; Wang, R. Asymmetric addition of benzothiazole to N-tert-butanesulfinyl imine for the synthesis of chiral a-branched heteroaryl amines, Tetrahedron Lett. 2012, 53, 6893–6896.

[6] Lin, Li; Fu, X.; Ma, X. J.; Zhang, J. L.; Wang, R. Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives, Synlett, 2012, 23, 2559-2563.

[7] Lin, Li; Zhang, J. L.; Wang, R. One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Alkynes and Activated Nitroalkanes, Asian J. Org. Chem., 2012, 1, 222-225.

[8] Lin, Li; Yin, W.; Fu, X.; Zhang, J. L.; Ma, X. J.; Wang, R. Asymmetric Cyanation of Nitroalkenes Catalyzed by A Salen-Titanium Catalyst, Org. Biomol. Chem., 2012, 10, 83-89.

[9] Lin, Li; Zhang, J. L.; Ma, X. J.; Fu, X.; Wang, R. Bifunctional 3, 3’-Ph2-BINOL-Mg Catalyzed Direct Asymmetric Vinylogous Michael Addition of α, β-Unsaturated γ-Butyrolactam, Org. Lett., 2011, 13, 6410-6413.

[10] Song, H. J.; Yin, W.; Zeng, Q.; Jia, H. Z.; Lin, Li; Liu, X. D.; Mu, L. Y.; Wang, R. Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor, Int. J. Biochem. Cell. 2012, 44, 1410-1421.

[11] 王锐，林利，宋虹瑾，γ-羟基炔酸酯衍生物及其在制备抗肿瘤药物中的应用，国家发明专利：201110184445.6。(已授权)

[12] 王锐，林利，李阿妮，一种由γ-羟基烯酸酯合成γ-羰基酯化合物的制备方法，国家发明专利：201110008181.9。

[13] 王锐，林利，伏旭，一种手性α-氨基酸衍生物的制备方法，国家发明专利：201110327023.X。